3-Methyl-4-pyridinamine → HCID 11710361, compound

HRID 2404499Notes

Reaction equation

HRID 2404499 reaction equation
F[C:2]1[CH:7]=C[CH:5]=[C:4](F)[C:3]=1[NH:9][C:10]([C:12]1[S:13][C:14](C2C=C(C(F)(F)F)C=CC=2Cl)=[CH:15][CH:16]=1)=[O:11].[CH3:28][O:29][C:30](=[O:39])[C:31]1[CH:36]=[CH:35][C:34]([CH3:37])=[C:33](I)[CH:32]=1.CC1[CH:42]=[N:43]C=CC=1N>>[CH3:28][O:29][C:30](=[O:39])[C:31]1[CH:36]=[CH:35][C:34]([CH3:37])=[C:33]([C:14]2[S:13][C:12]([C:10](=[O:11])[NH:9][C:3]3[CH:2]=[CH:7][N:43]=[CH:42][C:4]=3[CH3:5])=[CH:16][CH:15]=2)[CH:32]=1

Participants

4

Reactant 3

HCID 748113-Methyl-4-pyridinamineHCID 11553502HCID 11553502, compoundHCID 13614033Methyl 3-iodo-4-methylbenzoate

Product 1

HCID 11710361HCID 11710361, compound

Procedure

Compound 4 was synthesized in an analogous fashion as described for Compound 1 except that 3-iodo-4-methyl-benzoic acid methyl ester was used instead of 1-chloro-2-iodo-4-trifluoromethyl-benzene in step 1, and 3-methyl-4 amino pyridine was used instead of 2,6-difluoroaniline in step 2.

Sources & evidence

ORD record
ord-1fadf5210d4244379646cd3d3d1aec05
Source dataset
uspto-grants-2014_08
Patent number
US08802721B2

Reaction notes

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