HCID 86644461, compound → HCID 86644460, compound

Participants

Reaction Conditions

Reaction Steps

Then, 4.5 g of 5-acetylamino-1-(2-fluoro-4-methyl-5-methylsulfinylphenyl)-3-(2,2,3,3,3-pentafluoropropoxy)pyrazole was dissolved in 200 mL of acetic anhydride, followed by stirring at 120° C. for 6 hours. Acetic anhydride was distilled off under reduced pressure, the obtained residue was dissolved in 150 mL of ethanol, and 4.0 g of potassium carbonate was added, followed by stirring at room temperature for 12hours. Neutralization with a 6N hydrochloric acid aqueous solution was carried out, and extraction with ethyl acetate was carried out. The organic layer was dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure, and the obtained residue was purified by silica gel column chromatography (developing solvent ethyl acetate:hexane=1:4) to obtain 3.8 g of 5-acetylamino-1-(2-fluoro-4-methyl-5-mercaptophenyl)-3-(2,2,3,3,3-pentafluoropropoxy)pyrazole (1H-NMR (CDCL3/TMS δ (ppm) value) δ: 2.09 (3H, s), 2.38 (3H, s), 3.39 (1H, s), 4.66 (2H, t), 6.20 (1H, s), 7.09 (1H, d), 7.14 (1H, brs), 7.39 (1H, d)).

Provenance & Evidence