Sodium Carbonate → HCID 86644462, compound

Participants

Reaction Steps

Then, 1.5 g of 5-acetylamino-1-(2-fluoro-4-methyl-5-mercaptophenyl)-3-(2,2,3,3,3-pentafluoropropoxy)pyrazole was dissolved in 20 mL of dimethylformamide, and 0.32 g of sodium carbonate and 1.5 g of 2-chloro-2,2-difluoroethyl nonafluorobutanesulfonate were added, followed by stirring at room temperature for 12hours. Then, extraction with ethyl acetate was carried out, the organic layer was dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure, the obtained residue was purified by silica gel column chromatography (developing solvent ethyl acetate:hexane=1:4) to obtain 1.3 g of 5-acetylamino-1-{2-fluoro-4-methyl-5-(2-chloro-2,2-difluoroethylthio)phenyl}-3-(2,2,3,3,3-pentafluoropropoxy)pyrazole.

Provenance & Evidence