Hydrochloric Acid → 7-[(5-cyclopropylpyrazin-2-yl)oxy]-2-{[3-(trifluoromethyl)phenyl]-sulfonyl}hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one

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Reaction Steps

To a solution of the product from Example 207C (40 mg, 0.107 mmol) in 1,4-dioxane (0.5 mL) was added a 4 M solution of hydrogen chloride in 1,4-dioxane (0.5 mL, 2.0 mmol). The resulting mixture was stirred at room temperature for 90 minutes and then concentrated in vacuo. To the residue was added CH2Cl2 (1 mL), 3-(trifluoromethyl)-benzene-1-sulfonyl chloride (0.021 mL, 0.130 mmol) and triethylamine (0.045 mL, 0.324 mmol), and the resulting mixture was stirred at room temperature for 90 minutes. The mixture was partitioned between water and CH2Cl2, and the organic layer was dried over Na2SO4. The drying agent was removed by filtration, and the filtrate was concentrated in vacuo. The crude product was purified by column chromatography on silica gel using a solvent gradient of 0-5% CH3OH in CH2Cl2 to give the title compound (47 mg, 90%). 1H NMR (300 MHz, CDCl3) δ ppm 0.84-1.04 (m, 4H) 1.55-1.65 (m, 0.6H) 1.89-2.50 (m, 4H) 2.85-2.98 (m, 0.4H) 3.00-3.20 (m, 1H) 3.69-3.84 (m, 0.4H) 3.83-3.96 (m, 1.6H) 3.95-4.07 (m, 1H) 4.20 (dd, J=13.22, 2.37 Hz, 1H) 5.43 (dd, J=8.14, 5.09 Hz, 0.6H) 5.57 (t, J=7.63 Hz, 0.4H) 7.74 (t, J=7.80 Hz, 1H) 7.86-7.99 (m, 3H) 8.00-8.04 (m, 1H) 8.07-8.13 (m, 1H); MS (ESI) m/z 483 (M+H)+.

Provenance & Evidence