Hydrochloric Acid → HCID 178493588, compound

Participants

Reaction Steps

Then, 0.65 g of 2-acetyl-1-{2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenyl}-5-methoxypyrazol-3-one was dissolved in 20 mL of tetrahydrofuran, and 0.2 g of potassium hydroxide was added, followed by stirring at room temperature for 2 hours. Concentrated hydrochloric acid was added to adjust pH to 3, the solvent was distilled off under reduced pressure, and extraction with ethyl acetate was carried out. The organic layer was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure to obtain 0.57 g of 1-{2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenyl}-3-hydroxy-5-methoxypyrazole.

Provenance & Evidence