Tert-Butyl nitrite → HCID 68480474, compound

Participants

Reaction Steps

Then, 1.48 g of ethyl-5-amino-3-ethoxy-1-{2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenyl}pyrazole-4-carboxylate was dissolved in 50 mL of tetrahydrofuran, and 0.44 g of tert-butyl nitrite was added under cooling with ice, followed by stirring at room temperature for 12 hours. Then, the solvent was distilled off under reduced pressure, and the obtained residue was purified by column chromatography (developing solvent ethyl acetate:hexane=1:4) to obtain 1.18 g of ethyl-3-ethoxy-1-{2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenyl}pyrazole-4-carboxylate.

Provenance & Evidence