Water → HCID 60142471, compound

HRID 2404605Notes

Reaction equation

HRID 2404605 reaction equation
[C:1]1([C@H:7]([CH3:30])[C:8]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C@@:17]3([OH:29])[CH2:23][C@H:22]4[CH2:24][C@H:19]([CH2:20][CH2:21]4)[C@@H:18]3[CH2:25][N:26]([CH3:28])[CH3:27])[CH:12]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.C[Si]([Cl:36])(C)C>CC(=O)CC>[ClH:36].[C:1]1([C@H:7]([CH3:30])[C:8]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C@@:17]3([OH:29])[CH2:23][C@H:22]4[CH2:24][C@H:19]([CH2:20][CH2:21]4)[C@@H:18]3[CH2:25][N:26]([CH3:28])[CH3:27])[CH:12]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 962WaterHCID 6397ChlorotrimethylsilaneHCID 60142472HCID 60142472, compound

Product 1

HCID 60142471HCID 60142471, compoundYield 79.4%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

Stir a solution of (S)-2-phenylpropanoic acid (300 mg, 2.0 mmol) in 5 mL of oxalyl chloride for 3 hours at room temperature. After removal of solvent under vacuum, (S)-2-phenylpropanoyl chloride is obtained as pole yellow oil. Dissolve the oil in 10 mL of CH2Cl2. Add (1S,2R,3R,5R)-2-((dimethylamino)methyl)-3-(3-hydroxyphenyl)bicyclo[3.2.1]octan-3-ol (400 mg, 1.45 mmol) and Et3N (293 mg, 2.9 mmol) to the solution. Stir the resultant mixture at room temperature for additional 3 hours. After addition of 20 mL of water, basify the mixture with K2CO3 to pH=10, and extract the aqueous mixture with EtOAc (20 mL×3). The combined organic layers are washed with brine (20 mL), dried over Na2SO4, filtered, and concentrated under vacuum. Purify the residue by silica gel chromatography (CH2Cl2:MeOH=30:1) to afford (S)-3-((1S,2R,3R,5R)-2-((dimethylamino)methyl)-3-hydroxybicyclo[3.2.1]octan-3-yl)phenyl 2-phenylpropanoate (500 mg, 84.7%; MS (m/z): 408 (M+1)) as yellow oil. Stir (S)-3-((1S,2R,3R,5R)-2-((dimethylamino)methyl)-3-hydroxybicyclo[3.2.1]octan-3-yl)phenyl 2-phenylpropanoate (250 mg, 0.61 mmol) with H2O (11 mg, 0.61 mmol) and TMSCl (66 mg, 0.61 mmol) in 2-butanone (5 mL) for 3 hours. Collect the precipitate by filtration to afford (S)-3-((1S,2R,3R,5R)-2-((dimethylamino)methyl)-3-hydroxybicyclo[3.2.1]octan-3-yl)phenyl 2-phenylpropanoate hydrochlorid (215 mg, Yield: 79.3%) as white solid. The absolute configuration of its hydrochloride salt form was confirmed by x-ray analysis. 1H NMR (400 MHz, DMSO) δ 9.81 (br, 1H), 7.31-7.41 (m, 7H), 7.14 (s, 1H), 6.87-6.90 (m, 1H), 5.01 (s, 1H), 4.08-4.10 (m, 1H), 3.02-3.08 (m, 1H), 2.42-2.58 (m, 4H), 2.12-2.26 (m, 6H), 1.90-1.99 (m, 2H), 1.75-1.80 (m, 2H), 1.51-1.59 (m, 6H).

Workup

  1. customCollect the precipitate
  2. filtrationby filtration

Sources & evidence

ORD record
ord-041ca53675ef49b19930e8cde725ff07
Source dataset
uspto-grants-2014_08
Patent number
US08802728B2

Reaction notes

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