4-Chloro-2-isocyanato-1-methoxybenzene → 1-(5-chloro-2-methoxyphenyl)-3-(1H-indol-4-yl)urea

Beteiligte Stoffe

Reaktionsschritte

A solution of 5-chloro-2-methoxyphenyl isocyanate (Int-4, 5.5 g, 30 mmol) in DCM (20 mL) was added dropwise to the 4-amino-1H-indole in DCM (30 mL) from Step A, and the resulting mixture was stirred overnight, then filtered to give the crude product 1-(5-chloro-2-methoxyphenyl)-3-(1H-indol-4-yl)urea (6.6 g, 70%), which was used directly in the next step without purification.

Herkunft & Nachweise