Hydrochloric Acid → HCID 68749223, compound

Participants

Reaction Steps

1-(2-Methoxyl-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-2,3-dihydro-1H-indol-4-yl}urea (500 mg, 0.92 mmol) was added to a 25% HCl in methanol solution. The resulting reaction mixture was stirred at rt overnight, then concentrated to afford the product 1-(2-methoxyl-5-chlorophenyl)-3-[1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-2,3-dihydro-1H-indol-4-yl]urea hydrochloride (412 mg, 93%).

Provenance & Evidence