HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[(4-nitro-1H-indol-1-yl)methyl]-1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridine → 4-[(4-amino-1H-indol-1-yl)methyl]-1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[(4-nitro-1H-indol-1-yl)methyl]-1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridine | HCID 68748411 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[(4-amino-1H-indol-1-yl)methyl]-1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridine | HCID 68749007 | 95.5% |
Reaction Steps
In a round-bottom flask was added 4-[(4-nitro-1H-indol-1-yl)methyl]-1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridine (500 mg, 1.3 mmol), Palladium on carbon (50 mg, 10%), and THF (30 mL). The mixture was stirred under a hydrogen atmosphere for 2 h, then filtered, concentrated to afford 4-[(4-amino-1H-indol-1-yl)methyl]-1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridine (450 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08648086B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-acc086089f984604bbb8543e8607f3a4 |
| Source note | uspto-grants-2014_02 |