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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 240476생성일: 2026년 10월 25일

Hydrochloric Acid → 1-(2-Methoxyl-5-chlorophenyl)-3-[1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-1H-indol-4-yl]urea hydrochloride

https://huagongshe.com/reaction/240476

반응식

참여 물질

역할이름HCID투입량
반응물Hydrochloric AcidHCID 313—
반응물1-(2-Methoxyl-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-1H-indol-4-yl}ureaHCID 68750472—
용매MethanolHCID 887—
생성물1-(2-Methoxyl-5-chlorophenyl)-3-[1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-1H-indol-4-yl]urea hydrochlorideHCID 68754864180.3%

반응 단계

1-(2-Methoxyl-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-1H-indol-4-yl}urea (500 mg, 0.92 mmol) was added to 25% HCl in methanol solution. The mixture was stirred overnight, then concentrated to afford the product 1-(2-Methoxyl-5-chlorophenyl)-3-[1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-1H-indol-4-yl]urea hydrochloride (400 mg, 90%).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08648086B2
출처 데이터셋uspto-grants-2014_02
ORD IDord-29696fe633d2498fad682d24d391b21c
출처 메모uspto-grants-2014_02