HCID 66674656, compound → HCID 57567307, compound

HRID 2404835Notes

Reaction equation

HRID 2404835 reaction equation
C(OC([NH:8][CH2:9][C:10]1[CH:15]=[C:14]([NH:16][C:17]([C:19]2[C:28](=[O:29])[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[NH:21][CH:20]=2)=[O:18])[CH:13]=[CH:12][C:11]=1[C:30]([CH3:33])([CH3:32])[CH3:31])=O)(C)(C)C>CC#N>[NH2:8][CH2:9][C:10]1[CH:15]=[C:14]([NH:16][C:17]([C:19]2[C:28](=[O:29])[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[NH:21][CH:20]=2)=[O:18])[CH:13]=[CH:12][C:11]=1[C:30]([CH3:32])([CH3:33])[CH3:31]

Participants

3

Reactant 1

HCID 66674656HCID 66674656, compound

Product 1

HCID 57567307HCID 57567307, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

N-[3-(Aminomethyl)-4-tert-butyl-phenyl]-4-oxo-1′-1-quinoline-3-carboxamide (390) was synthesized following the general scheme above starting from [5-[(4-oxo-1H-quinolin-3-yl)carbonylamino]-2-tert-butyl-phenyl]methylaminoformic acid tert-butyl ester (465). HPLC ret. time 2.44 min, 10-99% CH3CN, 5 min gradient; ESI-MS m/z 350.3 (M+H)+.

Sources & evidence

ORD record
ord-5de7041e32a74dd296308ada90cfcf7b
Source dataset
uspto-grants-2014_08
Patent number
US08802700B2

Reaction notes

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