3,5-Dimethoxyaniline → 6-chloro-N-(3,5-dimethoxyphenyl)pyrazine-2-carboxamide

HRID 240491Notes

Reaction equation

HRID 240491 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8](Cl)=[O:9])[CH:5]=[N:4][CH:3]=1.[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:17]=[C:18]([O:20][CH3:21])[CH:19]=1)[NH2:16]>C(Cl)Cl>[Cl:1][C:2]1[N:7]=[C:6]([C:8]([NH:16][C:15]2[CH:17]=[C:18]([O:20][CH3:21])[CH:19]=[C:13]([O:12][CH3:11])[CH:14]=2)=[O:9])[CH:5]=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 663013,5-DimethoxyanilineHCID 151496716-Chloropyrazine-2-carbonyl chloride

Product 1

HCID 160724366-chloro-N-(3,5-dimethoxyphenyl)pyrazine-2-carboxamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from Example 15B was reacted with 3,5-dimethoxyaniline and TEA in CH2Cl2 as described in Example 15C to afford the title compound. MS (DCI/NH3) m/z 294 (M+H)+.

Sources & evidence

ORD record
ord-b54d3e8fccf04a6d8e5a22ec6e1bea0d
Source dataset
uspto-grants-2014_02
Patent number
US08648084B2

Reaction notes

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