Glycerol → (3S,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-one

HRID 2404932Notes

Reaction equation

[Ca].[OH2:2].[OH:3][CH2:4][CH:5]([CH2:7][OH:8])[OH:6]>>[OH:3][CH2:4][C:5]([C@H:7]([C@H:7]([C@@H:5]([CH2:4][OH:3])[OH:6])[OH:2])[OH:8])=[O:6]

Participants

Reactant 3

HCID 753Glycerol

HCID 962Water2×

HCID 5460341Calcium

Product 1

HCID 92092(3S,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-one

Procedure

passing the isomerized reactor mixture to a second SMB zone comprising a plurality of adsorbent columns containing a strong acid cation calcium exchange resin stationary phase and operating in a 2-3-2-2 SMB cycle with water as a desorbent to provide a second extract stream comprising substantially pure d-tagatose, water, and glycerol and a second raffinate stream comprising substantially pure d-galactose, water, salts and a minor portion of d-tagatose;

Sources & evidence

ORD record: ord-138d529db7ad4e1dbc6a5154f885c2ef
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08802843B2

Reaction notes

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