Phosphorus tribromide → 1-(2-Bromoethyl)-4-chlorobenzene

HRID 2404935Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9]O)=[CH:4][CH:3]=1.P(Br)(Br)[Br:12]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][Br:12])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 24614Phosphorus tribromide

HCID 74647p-Chlorophenethylic alcohol

Product 1

HCID 230291-(2-Bromoethyl)-4-chlorobenzene

Procedure

In Stage 1, the 2-(4′-chlorophenyl)ethanol was reacted with phosphorous tribromide to give 2-(4′-chlorophenyl)ethyl bromide. The product was isolated directly from an aqueous quench without the need of an extractive solvent.

Sources & evidence

ORD record: ord-e36bc58095e142a5b3ba0bc5954913c4
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08802845B2

Reaction notes

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