4-Fluorobenzylic alcohol → HCID 86635810, compound

HRID 240495Notes

Reaction equation

HRID 240495 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][CH:3]=1.CC(C)([O-])C.[K+].[Cl:16][C:17]1[CH:22]=[N:21][CH:20]=[C:19](Cl)[N:18]=1>CS(C)=O>[Cl:16][C:17]1[CH:22]=[N:21][CH:20]=[C:19]([O:7][CH2:6][C:5]2[CH:8]=[CH:9][C:2]([F:1])=[CH:3][CH:4]=2)[N:18]=1

Participants

5

Reactant 3

HCID 680224-Fluorobenzylic alcoholHCID 785042,6-DichloropyrazineHCID 23665647Potassium tert-butoxide

Product 1

HCID 86635810HCID 86635810, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

4-Fluorobenzylalcohol (200 μL, 1.85 mmol) and potassium tert-butoxide (122.1 mg, 1.00 mmol) in anhydrous DMSO (1 mL) were reacted with 2,6-dichloropyrazine (156.8 mg, 1.05 mmol) as described in Example 19B to afford the title compound. MS (DCI/NH3) m/z 239 (M+H)+.

Sources & evidence

ORD record
ord-22484146bb4c483687b0d170e5de1072
Source dataset
uspto-grants-2014_02
Patent number
US08648084B2

Reaction notes

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