Hydrogen Bromide → Prasugrel hydrobroMide

Participants

Reaction Conditions

Reaction Steps

Prasugrel base (1.00 g) was dissolved in acetone (15.5 ml) at 20-25° C. Solution of 0.34 ml 47% HBr in 4.8 ml of acetone was added in solution of base. Clear solution was cooled down to 5-0° C. After 5 minutes crystallization took place. Suspension was stirred at 5-0° C. for 2 hours, filtered, crystals were washed with acetone and dried at 40° C./vacuum, yielding form II of prasugrel hydrobromide (1.26 g). HPLC purity: 99.94%.

Provenance & Evidence