Hydrogen Bromide → Prasugrel hydrobroMide

Participants

Reaction Conditions

Reaction Steps

To a solution of prasugrel base (0.998 g) in acetone (16 ml) at 20-25° C. under nitrogen atmosphere was added dropwise a solution of 0.34 ml 47% HBr(aq) in 4 ml of acetone. Crystallization occurred during the addition. After 30 minutes, the resulting suspension was cooled down to 5-0° C. and stirred for 2 hours. Crystals were filtered off under a nitrogen atmosphere, washed with 6 ml of acetone ((4+2) ml in portions) and dried at 30° C./10 mbar for about 45 minutes. Form II of Prasugrel hydrobromide (1.269 g) was obtained.

Provenance & Evidence