Hydrogen Bromide → Prasugrel hydrobroMide

Participants

Reaction Steps

Prasugrel base (5.00 g) was dissolved in 50.0 ml of methyl ethyl ketone. A solution of 1.7 ml of 47% HBr (aq) in 20 ml of methyl ethyl ketone was added. Prasugrel hydrobromide crystallized after 5 minutes. The resulting suspension was stirred at room temperature for 1 hour and then 0.5 hours at 0-5° C. The crystals that formed were filtered, washed with methyl ethyl ketone and dried at 50° C./vacuum, yielding 6.06 g of prasugrel hydrobromide.

Provenance & Evidence