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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 240502Generated: October 26, 2026

5-bromo-N-(2-methylbenzyl)nicotinamide → (3aS,6aS)-tert-butyl 1-(5-(2-methylbenzylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate

https://huagongshe.com/reaction/240502

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-bromo-N-(2-methylbenzyl)nicotinamideHCID 9104610—
Reactantrac-tert-butyl (3aR,6aR)-octahydropyrrolo(3,4-b)pyrrole-5-carboxylateHCID 16227750—
Product(3aS,6aS)-tert-butyl 1-(5-(2-methylbenzylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylateHCID 67265849—

Reaction Steps

Prepared from (3aS,6aS)-tert-butyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate (prepared as described in WO2001081347) and the product from Example 31A using the procedure as described in Example 31B. MS (APCI) m/z 437 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08648084B2
Source datasetuspto-grants-2014_02
ORD IDord-1c96f6eb015a42a3a9c692486a6198fe
Source noteuspto-grants-2014_02