Hydrochloric Acid → HCID 70872103, compound

Participants

Reaction Steps

To a stirred solution of 0.045 g of [(4-{2-[2-(4-amino-furazan-3-yl)-benzoimidazol-1-yl]-acetyl}-phenylcarbamoyl)-methyl]-carbamic acid tert-butyl ester (0.09 mmol; 1 eq.) in 0.5 mL of 1,4-dioxane are added dropwise 0.11 mL of a 4M HCl solution in 1,4-dioxane (0.44 mmol; 5 eq.) at room temperature. The reaction mixture is stirred for 2 h at room temperature. Then, 5 mL of diisopropylether are added and the resulting suspension is filtered, washed with diisopropylether (2×2 mL) and dried under reduced pressure to give 0.04 g of crude material. The crude solid is subjected to MCI gel column chromatography eluting with a mixture water/acetonitrile (85/15 to 70/30) containing 0.05% of HCl, to afford 0.014 g of the desired product as an orange powder.

Provenance & Evidence