2-Chloroethanol → HCID 86614857, compound

Participants

Reaction Steps

2-(2,2,2-Trifluoro-acetyl)-6-trifluoromethyl-1H-benzoimidazole-5-carbonitrile (0.50 g; 1.5 mmol), was dissolved in DMF (4 mL), then treated with 2-chloroethanol (0.35 mL; 5.2 mmol) and potassium carbonate (0.73 g; 5.3 mmol). The reaction mixture was stirred at room temperature overnight. The reaction mixture was then diluted with ethyl acetate (40 mL) and diethyl ether (40 mL), washed with water (50 mL) and brine (3×30 mL), then dried over Na2SO4. The reaction mixture was filtered, concentrated to yield a light brown solid, which was purified by column chromatography (SiO2; 100% ethyl acetate) to yield the title compound as a light yellow solid.

Provenance & Evidence