Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 240511Generated: October 25, 2026

m-Toluidine → (3aR,6aS)-tert-butyl 5-(5-(m-tolylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

https://huagongshe.com/reaction/240511

Reaction equation

Participants

RoleNameHCIDCharge
Reactantm-ToluidineHCID 7934—
Reactant5-((3aR,6aS)-5-(tert-butoxycarbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)nicotinic AcidHCID 67265367—
Product(3aR,6aS)-tert-butyl 5-(5-(m-tolylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylateHCID 67265576—

Reaction Steps

The product from Example 33B and m-toluidine were processed as described in Example 33C to provide the title compound. MS (APCI) m/z 423 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08648084B2
Source datasetuspto-grants-2014_02
ORD IDord-43accc95daa647d8b58307d6333d2c42
Source noteuspto-grants-2014_02