Ethanol → HCID 57556125, compound

Participants

Reaction Steps

According to the general procedure 1, N-[4-(morpholin-4-ylsulfonyl)phenyl]thiourea (prepared from [4-(morpholin-4-ylsulfonyl)phenyl]amine (Maybridge), following procedure D) is added to a solution of N-[5-(bromoacetyl)-4-methyl-1,3-thiazol-2-yl]acetamide (Intermediate 1) in EtOH. The mixture is stirred 5 hours at RT. The solvents are evaporated and the desired product is purified by crystallization Compound (112) is isolated as a beige solid (24.82 mg; 19%). M+ (ESI): 480. HPLC, Rt: 8.55 min (purity: 96%).

Provenance & Evidence