Hydrochloric Acid → HCID 68194187, compound

Participants

Reaction Steps

According to the above-described scheme, 4-(2-ethoxy-1,1-difluoro-2-oxoethyl)benzoic acid ethyl ester (Compound 2d; 108.9 mg, 0.4 mmol) and 1N K2CO3 solution (1.5 mL) were put into an eggplant flask, and the mixture was stirred at room temperature for 26 hours. After the reaction, the reaction mixture was neutralized with 5% HCl solution, extracted with ethyl acetate and washed with water, and an organic layer was dried with anhydrous sodium sulfate. Ethyl acetate was distilled away under reduced pressure, and by carrying out purification by silica gel column chromatography, 4-(2-ethoxy-1,1-difluoro-2-oxoethyl)benzoic acid (Compound 4d) was obtained with a yield of 86%.

Provenance & Evidence