o-Iodonitrobenzene → HCID 68193918, compound

Participants

Reaction Conditions

Reaction Steps

According to the Kumadaki method (supra) and the above-described scheme, 2-iodonitrobenzene (Compound 1c; 250.0 mg, 1.0 mmol), bromodifluoroacetic acid ethyl ester (203 mg, 1.0 mmol), copper powder (128 mg, 2.0 mmol) and DMSO (2.0 mL) were put into a two-neck reaction tube, and the mixture was stirred under argon atmosphere at 55° C. for 15 hours. The reaction mixture was extracted with ethyl acetate and washed with water, and an organic layer was dried with anhydrous sodium sulfate. Ethyl acetate was distilled away under reduced pressure, and by carrying out purification by silica gel column chromatography, 2,2-difluoro-2-(2-nitrophenyl)acetic acid ethyl ester (Compound 2c) was obtained with a yield of 13%.

Provenance & Evidence