Acetone → HCID 57772128, compound

Participants

Reaction Steps

To a mixture of methyl 3(4-hydroxy phenyl)propionate (60 grams, 333 mmol), anhydrous K2CO3 (180 grams, 1.30 mol) in anhydrous acetone (1 liter) was added methyl chloro acetate (74.2 grams, 684 mmol) and refluxed for 40 hours. Acetone was distilled and water (1000 mL) was added. Crude 15 extracted into chloroform, distilled chloroform and high vacuum distilled to get pure 15 (30 grams, 36%) as a colorless low melting solid. Bp12 210-213° C. The structure was confirmed by NMR. IHNMR (CDCl3) δ 2.58 (t, 2H, CH2), 2.90(t, 2H, CH2), 3.62(s, 3H, ester), 3.80(s, 3H, ester), 4.60(s, 3H, OCH2), 6.80(d, 2H, Ar), 7.12(d, 2H, Ar).

Provenance & Evidence