HuagongsheHuagongshe Chemistry Print Report · For research reference only
Naproxen → Desmethylnaproxen
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Naproxen | HCID 156391 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | Desmethylnaproxen | HCID 162920 | — |
Reaction Steps
A mixture of Naproxen (500 grams, 2.774 mmol) and 48% HBr (1500 mL) was refluxed for 10 hours, poured onto ice water (3000 mL), and stirred for 30 minutes. Crude 29 was filtered, dried (380 grams, 81%), and used as such for the next stage.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802892B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-927e46c5dc214a78a9a0d61e88802c62 |
| Source note | uspto-grants-2014_08 |