Methyl 2-(2-(4-nitrophenoxy)ethoxy)acetate → HCID 59253936, compound

Participants

Reaction Steps

[2-(4-Nitrophenoxy)-ethoxy]acetic acid methyl ester 74 (1 grams, 3.9 mmol) was dissolved in anhydrous ethyl acetate (20 mL), palladium carbon (10%, 0.1 gram) added and the mixture stirred under an atmosphere of H using balloon for 30 minutes. The catalyst was filtered, the filtrate concentrate hexane (3 mL) added, filtered solid to give 75 (625 mg, 70.9%) as a light brown powder. The melting point was found to be 51-52.5° C. The structure was confirmed with IR and NMR. IHNMR (CDCl3) 3.04 (bs, 2H,NH2), 3.72 (s, 3H,ester), 3.88(t, 2H,OCH2), 4.08(t, 2H,OCH2), 4.20(s, 2H,OCH2), 6.58(d, 2H,Ar), 6.70(d,2H,Ar).

Provenance & Evidence