6-Aminobenzothiazole → HCID 67265382, compound

HRID 240519Notes

Reaction equation

HRID 240519 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][C@H:11]2[CH2:13][N:14]([C:16]3[CH:17]=[N:18][CH:19]=[C:20]([CH:24]=3)[C:21](O)=[O:22])[CH2:15][C@H:10]2[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:25][C:26]1[CH:34]=[CH:33][C:29]2[N:30]=[CH:31][S:32][C:28]=2[CH:27]=1>>[S:32]1[C:28]2[CH:27]=[C:26]([NH:25][C:21]([C:20]3[CH:24]=[C:16]([N:14]4[CH2:15][C@@H:10]5[CH2:9][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])[CH2:12][C@@H:11]5[CH2:13]4)[CH:17]=[N:18][CH:19]=3)=[O:22])[CH:34]=[CH:33][C:29]=2[N:30]=[CH:31]1

Participants

3

Reactant 2

HCID 682886-AminobenzothiazoleHCID 672653675-((3aR,6aS)-5-(tert-butoxycarbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)nicotinic Acid

Product 1

HCID 67265382HCID 67265382, compound

Procedure

The product from Example 33B and 6-aminobenzothiazole were processed as described in Example 33C to provide the title compound. MS (APCI) m/z 466 (M+H)+.

Sources & evidence

ORD record
ord-ba88c9a25cbd457d83bd6df8e29037f5
Source dataset
uspto-grants-2014_02
Patent number
US08648084B2

Reaction notes

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