Benzenamine, 3,5-bis(trifluoromethyl)- → HCID 86635812, compound

HRID 240520Notes

Reaction equation

HRID 240520 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][C@H:11]2[CH2:13][N:14]([C:16]3[CH:17]=[N:18][CH:19]=[C:20]([CH:24]=3)[C:21](O)=[O:22])[CH2:15][C@H:10]2[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:25][C:26]([F:39])([F:38])[C:27]1[CH:28]=[C:29]([CH:31]=[C:32]([C:34]([F:37])([F:36])[F:35])[CH:33]=1)[NH2:30]>>[F:25][C:26]([F:38])([F:39])[C:27]1[CH:28]=[C:29]([NH:30][C:21]([C:20]2[CH:24]=[C:16]([N:14]3[CH2:15][C@@H:10]4[CH2:9][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])[CH2:12][C@@H:11]4[CH2:13]3)[CH:17]=[N:18][CH:19]=2)=[O:22])[CH:31]=[C:32]([C:34]([F:35])([F:37])[F:36])[CH:33]=1

Participants

3

Reactant 2

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-HCID 672653675-((3aR,6aS)-5-(tert-butoxycarbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)nicotinic Acid

Product 1

HCID 86635812HCID 86635812, compound

Procedure

The product from Example 33B and 3,5-bis(trifluoromethyl)aniline were processed as described in Example 33C to provide the title compound. MS (APCI) m/z 545 (M+H)+.

Sources & evidence

ORD record
ord-c510d05225bf49f08c4b7fbeeaf22274
Source dataset
uspto-grants-2014_02
Patent number
US08648084B2

Reaction notes

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