Sulfuryl chloride → HCID 67076161, compound

HRID 2405219Notes

Reaction equation

HRID 2405219 reaction equation
[Cl:1][CH2:2][C:3]1[S:4][CH:5]=[CH:6][C:7]=1[CH2:8][Cl:9].S(Cl)([Cl:13])(=O)=O>C(O)(=O)C>[Cl:13][C:5]1[S:4][C:3]([CH2:2][Cl:1])=[C:7]([CH2:8][Cl:9])[CH:6]=1

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 14893914HCID 14893914, compound

Product 1

HCID 67076161HCID 67076161, compoundYield 40.3%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2,3-Bis-chloromethyl-thiophene (500 mg, 2.76 mmol) was dissolved in acetic acid (10 ml). Sulfuryl chloride (372 mg, 2.76 mmol) was added and the mixture was stirred for 1 h at room temperature. The mixture was partitioned between EA, water and an excess of solid sodium hydrogencarbonate and the aqueous phase extracted with EA. The combined organic extracts were dried over magnesium sulfate, filtered and evaporated to dryness to give 240 mg of the title compound.

Workup

  1. customThe mixture was partitioned between EA, water
  2. extractionan excess of solid sodium hydrogencarbonate and the aqueous phase extracted with EA
  3. dry with materialThe combined organic extracts were dried over magnesium sulfate
  4. filtrationfiltered
  5. customevaporated to dryness

Sources & evidence

ORD record
ord-2da7f5680cdf4d4cbe4c87b9f8f28f16
Source dataset
uspto-grants-2014_08
Patent number
US08802720B2

Reaction notes

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