3-Methylbenzeneethanol → 2-{[5-Acetyl-4-(2-m-tolyl-ethoxy)-thiophene-2-carbonyl]-amino}-indane-2-carboxylic acid

Participants

Role	Name	HCID	Charge
Reactant	3-Methylbenzeneethanol	HCID 74648	—
Reactant	2-Thiophenecarboxylic acid, 5-acetyl-4-hydroxy-, methyl ester	HCID 10608080	—
Reactant	methyl 2-amino-2,3-dihydro-1H-indene-2-carboxylate hydrochloride	HCID 45074056	—
Product	2-{[5-Acetyl-4-(2-m-tolyl-ethoxy)-thiophene-2-carbonyl]-amino}-indane-2-carboxylic acid	HCID 44482144	—

Reaction Steps

The title compound was synthesized by reaction of 5-acetyl-4-hydroxy-thiophene-2-carboxylic acid methyl ester with 2-(3-methylphenyl)-ethanol in analogy to step 1 of example 1, subsequent ester hydrolysis in analogy to example 2, reaction with 2-amino-indane-2-carboxylic acid methyl ester hydrochloride in analogy to step 1 of example 15, and ester hydrolysis in analogy to example 2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08802720B2
Source dataset	uspto-grants-2014_08
ORD ID	ord-b4c103c48903424ea6e470b48da0a5e0
Source note	uspto-grants-2014_08