HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 2-[4-Hydroxy-3-(2-m-tolyl-ethylamino)-benzoylamino]-indane-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | HCID 44482418 | HCID 44482418 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-[4-Hydroxy-3-(2-m-tolyl-ethylamino)-benzoylamino]-indane-2-carboxylic acid | HCID 67076628 | — |
Reaction Steps
10 mg of the compound of example 171 were dissolved in DCM and treated with 200 μl of a 1 M solution of boron tribromide in DCM for 5 h. A 2 M solution of sodium carbonate was added, and the mixture was evaporated in vacuo. The product was purified by preparative RP HPLC (water/ACN gradient).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802720B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-86970112006948f2b1cd2f35983e107e |
| Source note | uspto-grants-2014_08 |