HuagongsheHuagongshe Chemistry Print Report · For research reference only
rac-tert-butyl (3aR,6aR)-octahydropyrrolo(3,4-b)pyrrole-5-carboxylate → (3aS,6aS)-tert-butyl 1-(5-(3,5-difluorophenylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,2-c]pyrrole-5(1H)-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | rac-tert-butyl (3aR,6aR)-octahydropyrrolo(3,4-b)pyrrole-5-carboxylate | HCID 16227750 | — |
| Reactant | 5-bromo-N-(3,5-difluorophenyl)nicotinamide | HCID 41601149 | — |
| Product | (3aS,6aS)-tert-butyl 1-(5-(3,5-difluorophenylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,2-c]pyrrole-5(1H)-carboxylate | HCID 67265701 | — |
Reaction Steps
The product from Example 53A and (3aS,6aS)-tert-butyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate (prepared as described in WO2001081347) were processed as described in Example 53B to provide the title compound. MS (APCI) m/z=445 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08648084B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-9d83397f0d744df38e4a553f848171e8 |
| Source note | uspto-grants-2014_02 |