1,2,3,4-Tetrahydroisoquinoline → HCID 67265992, compound

HRID 240529Notes

Reaction equation

HRID 240529 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][C@H:11]2[CH2:13][N:14]([C:16]3[CH:17]=[N:18][CH:19]=[C:20]([CH:24]=3)[C:21](O)=[O:22])[CH2:15][C@H:10]2[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:25]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:28][CH2:27][NH:26]1>>[CH2:25]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:28][CH2:27][N:26]1[C:21]([C:20]1[CH:24]=[C:16]([N:14]2[CH2:13][C@@H:11]3[CH2:12][N:8]([C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[CH2:9][C@@H:10]3[CH2:15]2)[CH:17]=[N:18][CH:19]=1)=[O:22]

Participants

3

Reactant 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 672653675-((3aR,6aS)-5-(tert-butoxycarbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)nicotinic Acid

Product 1

HCID 67265992HCID 67265992, compound

Procedure

The product from Example 33B and 1,2,3,4-tetrahydroisoquinoline were processed as described in Example 33C to provide the title compound: MS (APCI) m/z 449 (M+H)+.

Sources & evidence

ORD record
ord-8b54aa020b8c4552a03f8c009067eb86
Source dataset
uspto-grants-2014_02
Patent number
US08648084B2

Reaction notes

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