HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 2-[4-Carboxymethoxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 2-Bromoacetamide | HCID 69632 | — |
| Reactant | 2-[4-Hydroxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid methyl ester | HCID 67076268 | — |
| Product | 2-[4-Carboxymethoxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid | HCID 67076497 | — |
Reaction Steps
The title compound was prepared in analogy to example 270 from the compound of step 1 of example 254 and 2-bromo-acetamide. In the final hydrolysis step, 6 equivalents of lithium hydroxide were used, resulting in the hydrolysis of the ester moiety and the acetamide moiety.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802720B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-aa89bf7c807b495daabc63c9c4d221b2 |
| Source note | uspto-grants-2014_08 |