2-(1,2-Benzoxazol-3-yl)acetic acid → 2-(4-Methyl-1,2,5-oxadiazol-3-yl)ethanol

HRID 2405301Notes

Reaction equation

HRID 2405301 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][C:11](O)=[O:12])=[N:2]1.[CH3:14][C:15]1[C:16]([CH2:20][C:21](O)=[O:22])=[N:17][O:18][N:19]=1>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11][OH:12])=[N:2]1.[CH3:14][C:15]1[C:16]([CH2:20][CH2:21][OH:22])=[N:17][O:18][N:19]=1

Participants

4

Reactant 2

HCID 3017292-(1,2-Benzoxazol-3-yl)acetic acidHCID 10849252-(4-Methyl-1,2,5-oxadiazol-3-yl)acetic acid

Product 2

HCID 3373612-(4-Methyl-1,2,5-oxadiazol-3-yl)ethanolHCID 122791422-(BENZO[D]ISOXAZOL-3-YL)ETHANOL

Procedure

In analogy to example 356, the starting compounds 2-(benzo[d]isoxazol-3-yl)-ethanol and 2-(4-methyl-furazan-3-yl)-ethanol were prepared from 2-(benzo[d]isoxazol-3-yl)-acetic acid and 2-(4-methyl-furazan-3-yl)-acetic acid, respectively.

Sources & evidence

ORD record
ord-192ddd7d8bce4361a779c97cc27a1142
Source dataset
uspto-grants-2014_08
Patent number
US08802720B2

Reaction notes

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