反应详情

温度

120 °C

To a suspension of N-(4-bromo-2-chlorophenyl)-2-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]acetyl}hydrazinecarboxamide (1.3 g, 2.93 mmol) in water (60 mL) was added K2CO3 (2.025 g, 14.65 mmol). The reaction flask was equipped with a reflux condenser and heated to reflux (bath=120° C.) with stirring. After 5 h (analysis by LCMS indicated no starting material remained), the reaction mixture was cooled to room temperature and filtered to collect a small amount of white precipitate (this was determined to contain very little product and was discarded). The aqueous filtrate was adjusted to pH˜5.5 with 1N aq HCl and extracted with ethyl acetate (2×). The combined organics were dried over Na2SO4, filtered, and evaporated to provide the title product (570 mg, 1.339 mmol, 46% yield) as a foam. The product was determined to be 75% pure by LCMS (UV214) and was carried on in the next step without further purification. 1H NMR (400 MHz, CDCl3) δ ppm 7.80 (dt, J=2.3, 5.7 Hz, 1H), 7.68-7.52 (m, 1H), 7.28-7.22 (m, 1H), 4.01-3.35 (m, 2H), 3.34-2.99 (m, 1H), 2.74-2.08 (m, 3H), 1.82-1.66 (m, 1H), 1.59-1.51 (m, 1H), 1.12-0.91 (m, 1H), 0.83-0.69 (m, 1H).

1. customThe reaction flask was equipped with a reflux condenser
2. temperatureheated
3. temperaturewas cooled to room temperature
4. filtrationfiltered
5. customto collect a small amount of white precipitate (
6. extractionextracted with ethyl acetate (2×)
7. dry with materialThe combined organics were dried over Na2SO4
8. filtrationfiltered
9. customevaporated