4-Bromoaniline → N-(4-bromophenyl)-2-nitroaniline

Participants

Reaction Steps

10 g (49.5 mmol) of 2-bromonitrobenzene, 13 g (163 mmol) of sodium acetate, and 10 g (59 mmol) of 4-bromoaniline were stirred at 180° C. for 8 hours in an argon atmosphere. After cooling the reaction solution to room temperature, the reaction solution was diluted with ethyl acetate, and filtered. After concentrating the filtrate, the residue was washed with methanol to obtain 3.8 g of (4-bromophenyl)-(2-nitrophenyl)amine as an orange crystal (yield: 22%).

Provenance & Evidence