Potassium Carbonate → methyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-(3-(ethyl(4-methoxy-4-oxobutyl)amino)propylcarbamoyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)benzoate

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-(3-(4-methoxy-4-oxobutylamino)propylcarbamoyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)benzoate (10 mg, 0.014 mmol) and potassium carbonate (5.69 mg, 0.041 mmol) in dioxane (1 mL) and acetonitrile (1.000 mL) was heated up at 78° C. for 3 hours, LCMS indicated the formation of desired product. The reaction mixture was quenched with distilled water (2 mL), extracted with DCM (3×2 mL). All the extracts were combined, dried over sodium sulfate, filtered and concentrated under reduced pressure to provide the title compound as a colorless oil (10 mg, 96%). LCMS: m/e 757.50 (M+H)+, 2.73 min (method 1).

Provenance & Evidence