Potassium Carbonate → HCID 67777526, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-(2-(benzylamino)ethylcarbamoyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)benzoate (50 mg, 0.071 mmol), methyl 2-bromoacetate (32.5 mg, 0.213 mmol) and potassium carbonate (29.4 mg, 0.213 mmol) in dioxane (1 mL) and acetonitrile (1 mL) was heated up at 78° C. for 3 hours. LCMS indicated the formation of desired product. The reaction mixture was quenched with distilled water, extracted with DCM (3×4 mL). All the extracts were combined, dried over sodium sulfate, filtered and concentrated under reduced pressure to provide the title compound as a white solid (45 mg, 82%). LCMS: m/e 777.48 (M+H)+, 3.12 min (method 1).

Provenance & Evidence