HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-(2-Methyl-4-nitrophenoxy)pyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 4-(2-methyl-4-nitrophenoxy)pyridin-2-ylcarbamate | HCID 66937340 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(2-Methyl-4-nitrophenoxy)pyridin-2-amine | HCID 23153065 | — |
Reaction Steps
To a solution of tert-butyl 4-(2-methyl-4-nitrophenoxy)pyridin-2-ylcarbamate (1.0 g, 2.90 mmol) in dichloromethane (28 mL) was added TFA (4 mL). After stirring at room temperature for 6 hours, the reaction mixture was concentrated under reduced pressure to provide the crude product that was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08648087B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-976a2f84746c485d8bbd97c52a310b21 |
| Source note | uspto-grants-2014_02 |