Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2,6-Lutidine | HCID 7937 | — |
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | 2-Phenylbenzimidazole | HCID 12855 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 66779832 | HCID 66779832 | 72% |
Reaction Steps
In a nitrogen atmosphere, 107 g of benzyl chlorocarbonate was added dropwise to a solution of 97 g of 2-phenylbenzimidazole and 107 g of 2,6-lutidine in 700 g of tetrahydrofuran, which was heated and stirred at 50° C. for 20 hours. After ordinary aqueous work-up, the insoluble was filtered off. The filtrate was concentrated, washed with hexane, and dried, obtaining 118 g of 1-benzyloxycarbonyl-2-phenylbenzimidazole (yield 72%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08808964B2 |
|---|
| Source dataset | uspto-grants-2014_08 |
|---|
| ORD ID | ord-5682cf080f4e4f76959b106efaa0065c |
|---|
| Source note | uspto-grants-2014_08 |
|---|
