Acetic Anhydride → HCID 178475361, compound

HRID 240564Notes

Reaction equation

HRID 240564 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([OH:11])=[CH:8][CH:9]=2)[C:4]([OH:12])=[N:3][CH:2]=1.[C:13](OC(=O)C)(=[O:15])[CH3:14]>N1C=CC=CC=1>[C:13]([O:11][C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[N:1]=[CH:2][N:3]=[C:4]2[OH:12])(=[O:15])[CH3:14]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 178515775HCID 178515775, compound

Product 1

HCID 178475361HCID 178475361, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of quinazoline-4,6-diol (20 g, 123 mmol) and acetic anhydride (186 mL, 1.97 mol) was heated to 100° C. in pyridine (30 mL) for 2 hours. After cooling to room temperature, ice (200 g) was slowly added to the reaction mixture. The precipitate was filtered, washed with cold water, and dried under high vacuum to provide the product (16.25 g, 65%) as pale yellow solid.

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with cold water
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-e570e07f42a3407aa6ad59a82bc7173d
Source dataset
uspto-grants-2014_02
Patent number
US08648087B2

Reaction notes

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