HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 240565Generated: October 26, 2026
Dimethylformamide → 4-Chloroquinazolin-6-yl acetate
https://huagongshe.com/reaction/240565
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 178475361 | HCID 178475361 | — |
| Product | 4-Chloroquinazolin-6-yl acetate | HCID 18967624 | 90% |
Reaction Steps
To a solution of 4-hydroxyquinazolin-6-yl acetate (12.0 g, 58.8 mmol) in thionyl chloride (50 mL) was added DMF (0.5 mL). After heating to 90° C. for 3 hours, the reaction mixture was concentrated under reduced pressure and azeotroped with toluene to provide the product (11.8 g, 90%) as off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08648087B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-acb70a8f0bf444479b6502866ef4df74 |
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| Source note | uspto-grants-2014_02 |
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