1,2-Dichloroethane → HCID 86690147, compound

Participants

Reaction Steps

Methyl 2-((3-phenylpropyl)amino)acetate (20.0 mg, 0.0965 mmol) and 5-phenylvaleric acid (22.0 mg, 0.116 mmol) were dissolved in 1 mL of well-dried DCM under argon condition, and EDC (55.5 mg, 0.289 mmol), HOBt (39.1 mg, 0.289 mmol) and DIPEA (82.7 μL, 0.482 mmol) were added and the reaction mixture was stirred for 20 hours at room temperature. Upon completion of the reaction, the reaction was terminated by adding 3 mL of water, and the reaction mixture was extracted with DCM (3 mL×4). The organic layer thus obtained was treated with anhydrous magnesium sulfate to remove water. The precipitate was filtered out and the resulting solution was concentrated by distillation under reduced pressure, and purified by column chromatography to obtain 34.2 mg (0.0931 mmol, 96%) of the desired compound.

Provenance & Evidence