Hydrochloric Acid → HCID 86690149, compound

Participants

Reaction Steps

Methyl 2-(N-octyloctanamido)acetate (44.7 mg, 0.136 mmol) was dissolved in 0.5 mL of methanol and then 100 μL of 20% aqueous sodium hydroxide solution was added. The reaction mixture was then stirred for 2 hours at room temperature. Upon completion of the reaction, the reaction solution was diluted with 3 mL of ethyl acetate and then neutralized by adding 200 μL of 10% aqueous hydrogen chloride solution. After removing water with anhydrous magnesium sulfate and filtering out the precipitate, the resulting solution was concentrated by distillation under reduced pressure and purified by column chromatography to obtain 36.5 mg (0.116 mmol, 86%) of the desired compound.

Provenance & Evidence