Water → HCID 86675568, compound

Participants

Reaction Conditions

Reaction Steps

3-butyl-6-methylheptan-2-one (5.00 g, 27.1 mmol) was dissolved in dry THF (70 ml). The solution was cooled to −15° C., and a suspension of LiAlH4 (3.5M, 2.7 ml, 9.45 mmol) was added over 15 minutes under stirring. After one hour at −15° C., a complete conversion was observed. The grey suspension was warmed to 0° C., and hydrolyzed by slow and successive addition of: water (0.36 g), 15% aqueous NaOH (0.36 g) and water (1.08 g). After warming to room temperature, the white precipitate was filtered, and the solvent removed under vacuum. The crude product was distilled bulb-to-bulb (Kugelrohr, oven 50° C., 0.2 mbar) (yield: 74.5%).

Provenance & Evidence