HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 240568Generated: October 31, 2026
Oxalyl chloride → (E)-4-(diMethylaMino)but-2-enoyl chloride
https://huagongshe.com/reaction/240568
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | (2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride | HCID 45358758 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (E)-4-(diMethylaMino)but-2-enoyl chloride | HCID 21917321 | — |
Reaction Steps
To (E)-4-(dimethylamino)but-2-enoic acid hydrochloride (110 mg, 0.664 mmol) in acetonitrile (1.5 mL) was added oxalyl dichloride (75.9 mg, 0.598 mmol) followed by one drop of DMF. After heating to 60° C. for 30 minutes, the mixture was cooled to room temperature and concentrated to 0.5 mL total volume. The resulting solution was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08648087B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-940ea291261347d392804a36dcf50bf6 |
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| Source note | uspto-grants-2014_02 |
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